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India’s First Homemade mRNA Vaccine Gets Permission To Start Human Trials

by The Outlooker Web Desk
December 11, 2020
in National
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New Delhi:

A vaccine being developed by the Pune-based Gennova has become India’s first homemade mRNA candidate to get permission for human clinical trial, the government said today. The mRNA vaccines do not use the conventional model to produce immune response.

“mRNA vaccine carries the molecular instructions to make the protein in the body through a synthetic RNA of the virus,” a government statement read.

The mRNA vaccines are considered safe as they are “non-infectious, non-integrating in nature, and degraded by standard cellular mechanisms”.

The vaccines developed by American companies Pfizer and Moderna, which are said to have over 90 percent efficacy, use the mRNA model.

AstraZeneca-Oxford’s Covishield vaccine, which has shown an efficacy of 70 percent and is being manufactured by the Serum Institute of India, uses the 50-year-old ‘adenovirus vector-based antigen’ platform.

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The company has developed the vaccine candidate in collaborating with HDT Biotech Corporation, a US firm.

“HGCO19 (the code name for the vaccine) has already demonstrated safety, immunogenicity, neutralization antibody activity in animals. The neutralizing antibody response of the vaccine in mice and non-human primates was comparable with the sera from the convalescent patients of COVID-19,” the statement read.

While the mRNA vaccines developed by the US companies require sub-zero temperature to remain stable, “HGCO19” is stable at 2-8 degrees Celsius for two months, the Centre said.

If approved, the new vaccine could prove to be more effective in the Indian conditions as it remains stable in normal refrigerator temperature and eliminates the need to develop cold storage infrastructure in remote parts of the country.

The Outlooker Web Desk

The Outlooker Web Desk

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